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性对接受化疗的瘤携带小鼠的炎症信号,身体组成和身体功能产生影响

Jessica L Halle¹, Quan Zhang^1,2, Dryden R Baumfalk³

¹Integrative Muscle Biology Laboratory, Division of Regenerative and Rehabilitation Sciences, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee, United States.

American journal of physiology. Cell physiology

|October 24, 2025

概括

性别影响了FOLFOX化疗如何影响结肠癌小鼠的炎症,身体组成和身体功能. 化疗改变了男性与女性的炎症性细胞因子关系,影响肌肉损耗和代谢并发症.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
药理学药理学是指药理学的学科.

背景情况:

癌症缓冲症是由炎症驱动的,性别影响着炎症反应.
抗癌治疗和性与炎症的相互作用,身体组成和身体功能仍然不太清楚.

研究的目的:

研究FOLFOX化疗对男性和女性CT26瘤携带小鼠的炎症性细胞因子,身体组成和身体功能的影响.

主要方法:

携带CT26瘤的BALB/c小鼠接受了三个周期的FOLFOX化疗.
测量了血炎性细胞因子 (IL-6,LIF,TNF-α),身体组成 (瘦身和后肢质量),以及肌肉p-STAT3.
分析了细胞因子,身体组成和身体功能之间的关联,考虑到性别和FOLFOX治疗.

主要成果:

福福克斯在两性中都减少了瘤质量.
CT26瘤增加了IL-6,LIF和TNF-α;FOLFOX在男性中减弱了IL-6和LIF,但在女性中诱导了IL-6和TNF-α.
在男性中,IL-6与瘦身和后肢质量负相关,肌肉p-STAT3与肌肉质量负相关;FOLFOX破坏了这些关联. 这些关联在女性中不存在或变化.

结论:

在结肠癌模型中,性在FOLFOX化疗期间显著影响炎症性细胞因子,身体组成和身体功能之间的关系.
雌性小鼠对FOLFOX表现出明显的炎症和生理反应,这需要进一步研究性别特异的癌症缓解症机制.

关键词:

福尔福克斯 (FOLFOX) 是一个结肠直肠癌是什么意思互白素-6 (IL-6) 是一种蛋白质.白血病抑制因子 (LIF)信号传感器和转录3的激活器 (STAT3)

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