在患有复杂先天性心脏病的新生儿中",心脑相互作用"
Lisa Sogerer-Herold1, Charlotte Foltin1, David Kronthaler2
1Clinic of Congenital Heart Disease and Pediatric Cardiology, German Heart Center, TUM University Hospital, Technical University of Munich, Munich, 80636, Germany.
概括
患有复杂先天性心脏病 (CHD) 的新生儿表现出大脑生长减少和不成熟. 这些发现表明,在手术干预之前,术后风险增加和潜在的神经发育障碍.
科学领域:
- 新生儿科学 新生儿科学
- 儿科神经学 儿科神经学
- 心脏病学 心脏病学
背景情况:
- 复杂的先天性心脏病 (CHD) 对新生儿的大脑发育构成风险.
- 诸如低可塑性左心综合征 (HLHS) 和大动脉转移 (TGA) 这样的疾病与大脑病理有关.
- 改变大脑生长是复杂心脏病的新生儿的一个问题.
研究的目的:
- 研究患有复杂心脏病的新生儿的大脑体积和未成熟的大脑结构.
- 为了比较新生儿的大脑发育与HLHS和TGA与健康对照.
- 为了确定这些高风险婴儿大脑异常的潜在早期指标.
主要方法:
- 分析新生儿脑MRI扫描的前性研究.
- 使用dHCP管道进行半自动细分.
- 包括51名患有复杂性心血管疾病 (HLHS/HLHC/UVH,TGA,大动脉门阻塞) 的新生儿和209名对照,不包括早产.
主要成果:
- 大脑MRI在57%的冠状动脉疾病新生儿中显示出异常,包括脑液空间扩大,灰色/白质损伤,中风,腹腔内血和鼻静脉血栓.
- 69%的冠状动脉疾病新生儿表现出大脑早产的迹象,相对于妊娠年龄.
- 与对照组相比,CHD新生儿观察到减少的内体积和扩大的CSF体积.
结论:
- 患有复杂心血管疾病的新生儿在手术前表现出脑部生长减少,脑损伤风险增加以及成熟度受损.
- 这些大脑变化可能会导致更高的外科手术风险.
- 确定大脑体积损失的特定模式可能有助于对神经发育障碍的风险进行分层.
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