基线fusobacterium丰富度预测了克罗恩氏病中乌斯特基努马布反应:一个前性的微生物群队列研究
Chengran Wang1, Yanping Hao2, Yunyun Liu3
1Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, China.
Microbial biotechnology
|October 24, 2025
概括
肠道细菌的组成影响克罗恩病 (CD) 治疗反应. 在CD患者中,高的Fusobacterium水平预测了对乌斯特基努马布 (UST) 治疗的反应较差,这表明一种潜在的生物标志物.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 克罗恩氏病 (CD) 是一种慢性炎症性肠病.
- 乌斯特基努马布 (UST) 是一种用于活性CD的生物疗法.
- 肠道微生物群在预测UST反应中的作用尚未完全理解.
研究的目的:
- 为了研究肠道微生物群组成和用UST治疗的CD患者的临床结果之间的关联.
- 为了识别潜在的微生物生物标志物用于UST反应.
主要方法:
- 预期招募51名正在接受UST治疗的活跃CD患者.
- 在基线和24周使用克罗恩病活动指数 (CDAI) 评估临床活性.
- 在基线和24周使用16SrRNA测序进行便微生物群的表征.
主要成果:
- 46.7%的患者在24周内实现了临床缓解,82.2%的患者在24周内实现了临床反应.
- 在缓解组中,Megamonas和Erysipelatoclostridium的基线丰富.
- 在非缓解组中更高的基线Fusobacterium丰度,与BMI和ALB负相关,与CRP正相关.
结论:
- 乌斯特基努马布 (UST) 在亚洲活跃克罗恩病 (CD) 患者中显示出临床疗效.
- 基线Fusobacterium丰富度升高可能表明对UST治疗的反应较差.
- Fusobacterium显示出作为CD中UST反应的预测生物标志物的潜力.
相关概念视频
Bacterial Flora of the Large Intestine
1.5K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.5K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
635
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
635
Inflammatory Bowel Disease II: Crohn's Disease
947
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
947
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
483
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
483


