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对于空间分离辐射疗法的等价-均-剂量优化

Ya-Nan Zhu¹, Weijie Zhang², Yuting Lin³

¹School of Mathematics, Harbin Institute of Technology, Harbin, China.

Technology in cancer research & treatment

|October 24, 2025

概括

使用等效均剂量 (EUD) 优化规划的空间分离放射治疗 (SFRT) 改善了瘤控制和器官节约. 这种新的方法减少了EUD,并增加了接受SFRT的患者的生存率.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
计算生物学计算生物学

背景情况:

与传统放射疗法 (CONV) 相比,空间分离放射疗法 (SFRT) 使用高峰谷剂量模式来增强瘤控制和器官节约.
传统的物理剂量指标不足以捕捉SFRT不均剂量分布的生物有效性.
相当均剂量 (EUD) 作为一种替代指标,用于评估在非均剂量场景中的生物有效性.

研究的目的:

开发和介绍一种新的SFRT治疗规划方法,包括等效均剂量 (EUD) 优化.
这是首个已知的方法,将EUD优化整合到SFRT规划中.

主要方法:

用统一的目标剂量进行质子GRID疗法,以仅剂量优化 (DO) 和联合剂量和峰值-谷-剂量比 (PVDR) 优化 (JDPO) 进行建模.
增强了SFRT治疗计划,包括EUD优化,基于线性二次细胞存活模型.
优化使用了对剂量-体积-直方体约束的代凸放松和对监测单元和EUD目标的乘数的线性交替方向方法.

主要成果:

在不同规划场景中,EUD优化成功降低了EUD值,并增加了生存率.
对于一个头患者来说,随着脑干EUD优化,脑干EUD显著下降 (例如,DO从5.52%降至3.86%).
随着EUD优化,脑干生存率大幅增加 (例如,从DO的72.9%增加到81.6%),同时保持PVDR.

结论:

在SFRT规划中成功开发了一种用于EUD优化的新方法.
这种方法有效地减少了EUD,并提高了生存率,提供了更好的治疗结果.
拟议的方法将生物有效性纳入治疗计划,优化SFRT交付.

关键词:

相当于均剂量的一致剂量.相反的优化反向优化空间分数放射疗法 (SFRT) 是一种空间分数放射疗法.治疗计划治疗计划

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