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Updated: Aug 4, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
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在多发性硬化症中,TRIM37介导的PEX5通过单双化稳定减轻了氧化应激和脱髓化,这是EAE和LPC诱导的实验模型的见解

Lai Jiang1,2, Yue Jin2, Yujia Han2

  • 1Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

PloS one
|October 24, 2025
PubMed
概括

TRIM37-PEX5轴在治疗多发性硬化症 (MS) 方面显示出前景. 提高TRIM37蛋白水平可以降低氧化应激,保护神经细胞,并促进多发性硬化模型中的髓修复.

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相关概念视频

Protein Import into the Peroxisomes01:27

Protein Import into the Peroxisomes

Cells contain membrane-bound organelles called peroxisomes that oxidize organic molecules by transferring hydrogen atoms to oxygen, producing hydrogen peroxide. Peroxisomes enzymatically convert the released hydrogen peroxide into water and oxygen.
Peroxisomal Protein Import:
Peroxisomes lack the genetic machinery required to code for their own proteins. Hence, most peroxisomal membrane, lumenal and transmembrane proteins are synthesized in the cytoplasm or ER and transported to the peroxisome...