相关实验视频

Updated: Jan 14, 2026

Isolation of Adipose Tissue Immune Cells

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

由脂肪甘油三糖 lipase 调节的脂解-微脂层驱动病原性适应性 2 型免疫

Hiroyuki Yagyu^1,2, Masahiro Kiuchi¹, Atsushi Sasaki^1,3,4

¹Department of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.

Science immunology

|October 24, 2025

概括

长链不和脂肪酸通过诱导特定的T助手2细胞来促进过敏性疾病. 这一过程涉及脂质液滴的储存和分解,为持久性过敏提供了新的治疗点.

科学领域:

免疫学免疫学免疫学
代谢过程中的代谢.
过敏性疾病过敏性疾病

背景情况:

记忆T助手2 (T_H2) 细胞表达ST2驱动过敏性疾病.
ST2^hi记忆T_H2细胞诱导的免疫代谢驱动因素是未知的.

研究的目的:

阐明底层ST2^hi记忆T_H2细胞生成的免疫代谢机制.
为了研究脂肪酸在过敏炎症中的作用.

主要方法:

慢性过敏气道炎症的小鼠模型.
对T_H2细胞脂质代谢的分析,包括脂质滴滴的吸收,储存和代谢.
研究脂肪甘油三糖 lipase (ATGL) 和氧酶增殖器激活受体 γ (PPARγ) 的作用.
从患有eosinophilic慢性鼻炎的患者获得的人类样本的分析.

主要成果:

长链不和脂肪酸 (LC-UFA) 在慢性过敏呼吸道炎症期间积累.
激活的T_H2细胞在脂质滴中吸收和储存LC-UFA.
由ATGL调节的脂质滴滴催化,激活PPARγ.
PPARγ诱导ST2表达,产生ST2效应体和记忆T2细胞.
在人类过敏性疾病中观察到微脂质和可访问的IL1RL1增强剂.

结论:

炎症环境衍生的LC-UFA对病原性适应性2型免疫非常重要.
LC-UFA的储存和代谢驱动ST2^hi记忆T_H2细胞的诱导.
这些发现揭示了对持续性过敏炎症的潜在治疗策略.

更多相关视频

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

相关概念视频

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Lipid Absorption

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...

Inflammation

Inflammation

Lipid Catabolism

Lipid Catabolism

Triglycerides serve as crucial long-term energy storage molecules in microorganisms, providing a dense source of metabolic energy. Their breakdown is mediated by lipases, which hydrolyze triglycerides into glycerol and free fatty acids. Each of these components follows distinct metabolic pathways, ultimately contributing to ATP synthesis and cellular energy homeostasis.Glycerol MetabolismGlycerol, released from triglyceride hydrolysis, is phosphorylated by glycerol kinase to form...