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多发性硬化症:质细胞激活 - - 生物标志物的进步及其转化意义

Weichen Zeng¹, Huixian Wu¹, Ying Huang¹

¹Department of Neurology, Jinshan Hospital of Fudan University, Shanghai, China.

Science progress

|October 24, 2025

概括

新的生物标志物揭示了质细胞激活的情况.

科学领域:

神经免疫学神经免疫学
多发性硬化症的病理生理学

背景情况:

目前的多发性硬化症 (MS) 诊断依赖于麦克唐纳标准,脑液分析和MRI,但这些在详细说明病原体学方面存在局限性.
质细胞激活,特别是星球细胞和微质细胞,越来越被认为是MS病变和神经元损伤的关键驱动因素.

研究的目的:

为了提供一个全面的概述质细胞病理生理学在MS.
突出与MS中微质和天体细胞损伤相关的新生物标志物.

主要方法:

综述最近神经成像,生物标志物发现和与MS相关的基因组分析方面的进展.
分析涉及在MS进展中的质细胞激活的研究.

主要成果:

质细胞激活是MS中一个中心的致病机制.
特定的质细胞子集在疾病进展和轴突损失中起着关键作用.
新兴的生物标志物显示出了解和向MS的质损伤的潜力.

结论:

了解质细胞子集对于开发向性多发性硬化疗法至关重要.
基于生物标志物的方法可以提高MS病理生理学的体内检查.
新型生物标志物为个性化多发性硬化症治疗策略提供了希望.

关键词:

多发性硬化症是多发性硬化症.星球细胞是星球细胞.生物标志物生物标志物状细胞是状细胞中的一种.微质细胞中的微质细胞

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