催化剂对肠道微生物群的排他性影响:针对集中系统审查和元分析的协议
Xiaotao Zhang1, Yueyue Guo1, Jia Shi1
1Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 200 Xianlin Avenue, Nanjing, 210023, China, 86 18205168666.
JMIR research protocols
|October 24, 2025
概括
催化剂可以通过减少有害细菌和增加有益的细菌来改变肠道微生物群 (GM). 这种传统疗法显示出改善肠道健康和非药物治疗慢性疾病的潜力.
科学领域:
- 微生物组研究的研究.
- 综合医学是一个整体的医学.
- 传统中国医药 传统中国医药
背景情况:
- 肠道微生物群 (GM) 显著影响全身健康,影响免疫,代谢和神经功能.
- 热疗法莫克西布斯可能会调节GM,但其具体效果尚不清楚.
- 现有的元分析缺乏关于moxibustion对微生物生态的影响的机制细节.
研究的目的:
- 系统地审查和分析莫克西布施对肠道微生物群的影响.
- 量化转基因多样性,分类组合和功能代谢物的变化.
- 为了区分moxibustion的独特影响与组合疗法.
主要方法:
- 在多个数据库 (PubMed,科学网等) 中进行系统搜索. 用于临床前和临床研究.
- 包括评估对转基因基因的独立莫克西布施干预措施的研究.
- 分析主要结果,包括微生物α多样性和关键种类的相对丰度.
- 偏差风险评估和聚合效应估计使用平均值与95%CI的比率.
主要成果:
- 确定了31项符合纳入标准的研究.
- 预期的结果表明,moxibustion可能会减少致病性属 (例如,Ruminococcus) 并增强有益的属.
- 与改善肠道屏障完整性和抗炎反应的预期关联.
结论:
- 该协议提供了一个框架来评估moxibustion在转基因调制中的独特作用.
- 结果将为微生物组相关慢性疾病的非药理学策略提供信息.
- 这些发现将指导传统医学和微生物组科学领域的未来研究重点.
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