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在消化系统恶性瘤中,基于血液营养素,炎症制造者,肠道功能指标和身体组成的精确营养诊断

Huaixing Ma¹, Jielin Zhou², Shoumei Yang²

¹Cheeloo College of Medicine, Shandong University, China; Department of Oncology Nutritional and Metabolic Therapy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.

Clinical nutrition (Edinburgh, Scotland)

|October 24, 2025

概括

精确营养诊断识别了L-三和维生素A等关键标志物,以准确评估癌症患者的营养不良,指导更好的治疗策略.

科学领域:

在瘤学瘤学.
营养科学营养科学
代谢学代谢学代谢学

背景情况:

营养不良显著恶化了癌症患者的结果,创造了炎症和肠道功能障碍的循环.
标准的营养疗法对于这些复杂的病例往往是不够的.

研究的目的:

为了探索癌症患者的精确营养诊断.
确定关键指标,结合血营养素,炎症标志物,肠道功能和身体组成.

主要方法:

分析了140名消化系统癌症患者的血代谢量,炎症标志物和肠道功能指标.
利用超高性能液态染色学-并联质谱学和全基因组测序来分析肠道微生物群.
将87名严重营养不良的患者 (PG-SGA ≥9) 与53名营养良好的对照 (PG-SGA ≤3) 进行比较.

主要成果:

确定了129种不同等离子体营养素,在营养不良患者中发现了l-三,尿素,维生素A和硫酸铁醇的显著减少.
在严重营养不良组中观察到炎症标志物 (例如IL-6) 和d-乳酸盐的升高,以及肠道微生物群异常和较低的BMI.
开发了一种精确营养诊断模型,使用六个关键标记物 (l-三,尿素,维生素A,甲基醇硫酸盐,IL-6,BMI) 具有高准确性 (AUC 0.979).

结论:

癌症患者的严重营养不良与鲜明的血液营养,炎症和肠道功能特征有关.
将这些多方面的指标整合起来,可以实现准确的营养诊断.
这种方法可以指导量身定制的营养干预措施,以改善临床结果.

关键词:

身体组成身体组成炎症因素炎症因素肠道功能肠道功能营养素营养素营养素精确的营养诊断诊断精确的营养诊断

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