患有维生素B12缺乏和神经特征的婴儿的神经发育结果
Juhi Gupta1, Pragati Jeenwal1, Sayoni Roy Chawdhary2
1Department of Pediatrics, SMS Medical College, Jaipur, Rajasthan, India.
概括
由维生素B12缺乏引起的婴儿震综合征 (ITS) 可以导致儿童的长期发育迟缓. 早期治疗可以改善症状,但长期的神经发育结果仍然令人担忧.
科学领域:
- 儿科 儿科 儿科
- 神经学 神经学
- 营养科学 营养科学
背景情况:
- 婴儿震综合征 (ITS) 是由婴儿维生素B12缺乏导致的.
- ITS可能导致全球发育延迟,回归和特征性的身体变化.
- 患有ITS的婴儿的长期神经发育结果没有得到充分的记录.
研究的目的:
- 评估被诊断患有婴儿震综合征的儿童的长期神经发育结果.
- 评估一组有ITS病史的儿童的社会分数 (SQ).
主要方法:
- 对35名有ITS病史的儿童 (年龄≥2岁) 进行了横截面研究.
- 神经发育结果使用马林对维尼兰社会成熟度表 (Vineland Social Maturity Scale, VSMS) 的调整进行了评估.
- 收集的数据包括评估时的年龄,随访时间和社会指数 (SQ) 评分.
主要成果:
- 评估时的平均年龄为30个月,平均随访时间为16.3个月.
- 只有26%的儿童有平均SQ (85-105).
- 显著的大多数,51%的人表现出边缘性残疾 (SQ 70-84),而其他人则表现出轻度至严重的残疾.
结论:
- 尽管治疗后最初有所改善,但患有ITS的婴儿经历了显著的长期发育迟缓.
- 这些发现强调了对ITS儿童神经发育结果的持续监测和支持的需要.
- 婴儿时期的维生素B12缺乏对神经发育有深刻而持久的影响.
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