年龄,而不是虚弱,与不确定的甲状腺结节的甲状腺切除术有关
Michel Kabbash1, Isabelle Snider2, Daniel Neal1
1Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.
The Journal of surgical research
|October 24, 2025
概括
老年,而不是脆弱,影响了关于甲状腺结节手术的决定. 在老年患者中,不确定的甲状腺结节更有可能被监测,而不是通过手术切除.
科学领域:
- 内分泌学 在内分泌学.
- 手术瘤学手术瘤学
- 老年医学 老年医学
背景情况:
- 不确定的甲状腺结节的管理 (贝塞斯达III和IV细胞学) 是复杂的.
- 手术干预的预测因素,特别是甲状腺切除术,需要进一步阐明.
- 患者年龄和脆弱性对这些结节的治疗决策的影响尚未完全理解.
研究的目的:
- 为了确定甲状腺切除术的预测因子,确定不确定的甲状腺结节.
- 具体评估患者年龄和脆弱性对进行手术的决定的影响.
主要方法:
- 从2010年到2022年,对377名患有未确定的甲状腺结节 (贝塞斯达III/IV) 的成年患者进行了回顾性分析.
- 对患者的人口统计,临床病史,结节特征和分子检测的审查.
- 计算每个患者的修改过的脆弱指数得分.
- 后勤回归分析以确定甲状腺切除术的预测因素.
主要成果:
- 57.4%的结节经历了甲状腺切除术.
- 年轻的年龄,较大的结节大小,贝塞斯达IV细胞学和积极的分子测试与甲状腺切除术有关.
- 在手术和监测组之间,脆弱指数得分没有显著差异.
- 多变量分析发现贝塞斯达IV细胞学和阳性分子测试增加了甲状腺切除术的可能性,而年龄较大和进行分子测试则降低了这种可能性.
结论:
- 年龄较大,而不是虚弱或并发症,与选择对未确定的甲状腺结节进行监测有关.
- 需要进一步的研究,以了解这些结节的老年人监测的长期结果.
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