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主要上肢截肢后的皮层脊髓失衡是通过连续的塔爆刺激暂时调节的

Emma Falato¹, Federico Ranieri², Gabriella Musumeci³

¹Research Unit of Neurology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Roma, Italy.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

|October 24, 2025

概括

主要的上肢截肢导致大脑不对称. 持续的甲爆刺激 (cTBS) 通过调节受影响半球的皮质脊髓刺激性 (CE) 暂时减少了这种不平衡.

科学领域:

神经科学是一个神经科学.
康复医学康复医学康复医学
发动机控制器的控制器

背景情况:

大型上肢截肢 (mULA) 会导致神经可塑性变化,影响康复和假肢使用.
以前的研究表明,截肢 (CLH) 的另一半球中皮质脊髓刺激性 (CE) 增加,这表明潜在的不适应性半球间失衡.

研究的目的:

在慢性mULA患者中评估基线CE.
为了研究持续的甲突破刺激 (cTBS) 对主要运动皮层 (M1) 应用的急性影响,与截肢对CE.

主要方法:

13名患有慢性mULA的成年人接受了电生理学评估.
运动唤起电位 (MEP) 幅度在cTBS前和之后在5分钟和10分钟测量.
线性混合模型分析了半球,时间及其相互作用的影响.

主要成果:

在CLH中观察到较高的MEP幅度,与基线时的ipsilateral半球相比.
在刺激后5分钟,cTBS在刺激后的CLH中暂时降低了MEP振幅.
这种减少导致半球间不对称的暂时减弱,在10分钟后部分恢复.

结论:

在慢性mULA患者中,cTBS可以暂时调节CE.
观察到的cTBS的影响似乎仅限于刺激的半球.
这项研究提供了mULA后半球间CE不对称性的初步证据,并建议cTBS作为潜在的调制工具,需要进一步调查.

关键词:

连续的塔爆刺激刺激.皮层脊髓的刺激能力主要的上肢截肢截肢.神经调节是一种神经调节.通过骨磁刺激来进行磁性刺激.

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