饮食城市化破坏了宿主肠道微生物群的稳定性,并为人类健康提供了精确营养信息
Fen Zhang1, Guicheng Zhou2, Matthias Schewe3
1Department of Food Science and Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China; Key Laboratory of Human Microbiome and Chronic Diseases (Sun Yat-sen University), Ministry of Education, Guangzhou, China.
Cell metabolism
|October 24, 2025
概括
城市化改变了人类的饮食和肠道微生物,增加了非传染性疾病. 针对微生物组的精密营养方法可以帮助抵消这些与城市化相关的疾病.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 公共卫生 公共卫生
背景情况:
- 自从工业革命以来,人类的饮食模式已经转向城市化,导致肠道微生物群的快速变化.
- 人类基因组的缓慢适应率使其潜在地易受与非传染性疾病 (NCD) 相关的微生物功能演变的影响.
研究的目的:
- 审查全球城市化期间饮食和非传染性疾病的时间变化.
- 突出肠道微生物组在城市化相关的健康转变中的中心作用.
- 提出一个微生物组导向的精密营养框架.
主要方法:
- 在全球城市化过程中绘制饮食模式的变化和非传染性疾病的发病率.
- 举例说明与城市化相关的肠道微生物的增加和损失.
- 描述饮食引起的宿主微生物组破坏的机制.
主要成果:
- 城市化的饮食破坏了宿主微生物群的相互作用,导致非传染性疾病.
- 在全球城市化过程中,肠道微生物组成发生了显著的变化.
- 人类基因组没有能力适应快速的,饮食驱动的微生物变化.
结论:
- 以微生物组为导向的精密营养框架可以整合种群变异,以促进宿主微生物组协同作用.
- 通过量身定制的饮食准微生物组提供了一种抵消城市化相关疾病的策略.
- 未来的研究应该专注于针对微生物的饮食,以预防非传染性疾病.
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