脉冲磁力超声波用于在磁热过热期间对软组织进行粘弹性表征

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Jose E Freire¹, David A Collazos-Burbano¹, Joao H Uliana¹

¹Department of Physics, FFCLRP, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

Physics in medicine and biology

|October 24, 2025

概括

这项研究整合了磁性高温 (MH) 和磁运动超声波 (MMUS) 来监测癌症治疗. 综合方法量化了MH治疗期间的组织变化,显示了实时治疗评估的潜力.

科学领域:

生物医学工程生物医学工程
在瘤学瘤学.
纳米技术纳米技术

背景情况:

磁性高温症 (MH) 使用磁纳米粒子 (MNP) 进行癌症切除.
磁运动超声波 (MMUS) 检测MNP并评估组织弹性.
整合MH和MMUS用于theranostics是未经探索的.

研究的目的:

开发一种结合MH和MMUS的治疗方法.
使用MMUS量化治疗诱导的粘弹性变化.
为了验证幽灵和活体肝脏的方法.

主要方法:

应用脉冲磁场用于基于MMUS的粘性弹性评估.
使用交替的射频磁场用于MH诱导的加热.
在参数估计中采用了与力无关的凯尔文-沃伊格特模型.

主要成果:

在没有先前MNP分布知识的情况下,量化了MH引起的变化.
确定了弹性,粘性和阻尼比率作为敏感的MMUS标记.
在MH后观察到弹性 (≥35%) 和粘性 (≥100%) 参数的显著增加.

结论:

实时监测MH癌症治疗的潜在潜力.
突出显示粘弹性参数作为治疗效应的敏感生物标志物.
建议进一步研究MH后的组织粘性弹性和水扩散.

关键词:

磁热过热是一种磁性过热.磁性纳米粒子是一种磁性纳米粒子.磁力发动超声波是一种超声波.热剂量的热剂量粘弹性特性粘弹性特性

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