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在小鼠中,局部用薄荷醇减轻和抑制脊柱微质激活
Shih-Ya Hung1, Tran Van Bao Quach2, Hsin-Yi Chung2
1Graduate Institute of Acupuncture Science, China Medical University, Taichung, 404328, Taiwan; Division of Surgery, Department of Medical Research, China Medical University Hospital, Taichung, 404327, Taiwan.
Journal of ethnopharmacology
|October 24, 2025
概括
薄荷薄荷的关键成分孟托尔,通过准TRPM8 (过渡受体潜力 melastatin 8) 通道并抑制脊柱微质激活,有效地减少. 这支持薄荷薄荷.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- 薄荷 (mentha piperita L.) 具有传统医疗用途的历史,特别是用于缓解 ().
- 薄荷醇是薄荷精油的主要成分,因其在调节的潜在神经药理作用而闻名.
研究的目的:
- 为了研究薄荷醇的抗机制.
- 评估薄荷醇对皮行为和脊柱微质激活在的小鼠模型的影响.
主要方法:
- 在小鼠中使用化合物48/80或GRP18-27诱导.
- 局部应用8%的薄荷醇和评估伤行为.
- 使用野生类型和Trpm8淘汰赛小鼠对TRPM8通道参与的评估.
- 通过免疫组织化学和西式涂抹,分析脊柱微质激活标记物 (Iba1,CD11b,-p38).
主要成果:
- 局部使用的薄荷醇显著降低了48/80化合物诱导的痕约63%和GRP18-27诱导的痕约61%.
- 薄荷醇的抗作用依赖于TRPM8,因为它被BCTC (TRPV1/TRPM8抗剂) 阻断,在Trpm8-/-小鼠中不存在.
- 薄荷应用减弱化合物48/80诱导的脊髓微质激活,减少Iba1和CD11b表达和-p38同位.
结论:
- 局部薄荷醇通过TRPM8依赖的机制缓解,该机制涉及抑制脊柱微质激活.
- 这些发现证实了胡薄荷用于缓解的传统用途.
- TRPM8和脊髓微质是治疗的潜在治疗点.
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