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Updated: Jan 14, 2026

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J-域蛋白与Hsp70合作,驱动缺少RNA结合的TDP-43多相分离

Kian Hua Yeo1, Jian Hua Kong1, Qing Hao Ng1

  • 1School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

The Journal of biological chemistry
|October 24, 2025
PubMed
概括

像Sis1这样的J域蛋白 (JDP) 对于形成与疾病相关的TDP-43多相凝结物至关重要. 这个过程涉及到Sis1招募Hsp70陪伴者,突出了JDP在TDP-43分相的特异性.

关键词:
在J-域蛋白 (JDP) 中.这是一种RNA结合蛋白.这种植物是Saccharomyces cerevisiae.在TAR中,DNA结合蛋白43 (TDP-43)肌缩侧面硬化症 (ALS) 是一种疾病.任何异构的部分.热冲击蛋白40 (Hsp40) 是一种热冲击蛋白.热冲击蛋白70 (Hsp70) 是一种热冲击蛋白.分子陪伴者分子陪伴者阶段分离的阶段分离.

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