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Updated: Jan 14, 2026

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
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重新研究CHK1和WEE1激酶作为癌症治疗点

Nehal Arvind Kumar1, P Manasa1, Jaikanth Chandrasekaran1

  • 1Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institution of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India.

Biochimica et biophysica acta. Reviews on cancer
|October 24, 2025
PubMed
概括

针对ATR-CHK1-WEE1轴,通过利用DNA损伤反应缺陷,为癌症治疗提供了一个新的策略. 抑制剂在选择性瘤细胞死亡的组合治疗中表现有前途.

关键词:
在ATR-CHK1-WEE1轴上这是一种CHK1抑制剂.癌症 癌症 癌症 癌症临床试验中的临床试验.DNA损伤反应 [DDR]基因组不稳定性 [GI]复制应力 (RS) 是一种复制应力.这是一种WEE1抑制剂.

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