尿道金属混合物和白内障:来自美国基于人口的研究和网络药理学分析的结果
Runzi Yang1, Jing Li1, Rui Liu1
1Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Toxicology letters
|October 24, 2025
概括
尿道金属暴露可能影响白内障风险. (Co) 显示出积极的关联,而 (Cd), (Pb) 和 (Ba) 显示出负面影响,需要进一步调查.
科学领域:
- 环境健康 环境健康
- 眼科医生 眼科 眼科
- 毒理学 毒理学 毒理学
背景情况:
- 在全球范围内,白内障是导致视力障碍的主要原因.
- 尿中的金属含量反映了最近的暴露和潜在的系统性影响.
- 了解与白内障相关的环境因素对于公众健康至关重要.
研究的目的:
- 调查尿液金属度与白内障患病率之间的关联.
- 为了确定特定的金属与白内障风险的正面或负面关联.
- 探索金属诱导白内障形成的潜在生物学机制.
主要方法:
- 分析了2207名参与者的国家健康和营养检查调查 (NHANES) 数据.
- 多变量逻辑回归用于评估金属白内障关系.
- 对于复杂的相互作用,加权量子总和 (WQS) 回归和贝叶斯内核机器回归 (BKMR).
- 网络药理学以阐明潜在的生物学途径.
主要成果:
- (Ba), (Sb) 和 (Tl) 与白内障患病率有显著的相关性.
- WQS发现了 (Cd), (Pb) 和Ba的强烈负面影响;对Tl和 (Co) 的积极影响.
- 在特定条件下,BKMR表明Co和白内障之间存在显著的正相关性,而Pb则存在负相关性. 干白素信号通路和AKT1都与此有关.
结论:
- 尿中的金属度可能与像白内障这样的眼部结果有关.
- (Co) 成为潜在的风险因素,而 (Pb) 在某些情况下显示出保护性关联.
- 需要进一步的纵向研究来证实这些发现并确定临床相关性.
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