发酵的甜菜汁加强紧密的结节,并通过多路调节缓解结肠炎
Yoon A Jeon1, Premkumar Natraj1, Young Jae Lee1
1College of Veterinary Medicine, Jeju National University, Jeju 63243, Republic of Korea; Veterinary Medical Research Institute, Jeju National University, Jeju 63243, Republic of Korea.
Fitoterapia
|October 24, 2025
概括
发酵甜菜汁 (BM) 显示出显著的抗炎和肠道保护作用. 这种饮食干预有效地减少了结肠炎症状,并增强了肠道屏障功能.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 性结肠炎 (UC) 是一种慢性炎症性肠病,治疗选择有限.
- 正在探索饮食干预措施的潜力,以管理UC.
- 发酵的甜菜汁 (BM) 含有生物活性化合物,如贝塔宁和Levon类多糖.
研究的目的:
- 研究发酵甜菜汁 (BM) 的抗炎和肠道保护作用.
- 在大肠炎的小鼠模型和体外细胞模型中评估BM的疗效.
主要方法:
- BM及其水溶性分量的化学表征 (BM-WS).
- 在体外测定使用巨细胞 (RAW264.7,RAW-BlueTM) 和Caco-2细胞.
- 在体内研究使用德克斯硫酸盐 (DSS) 诱导的大肠炎小鼠模型.
主要成果:
- 在体外,BM和BM-WS抑制了LPS诱导的氧化,活性氧物种,NF-κB,COX-2和NLRP3的激活.
- 在大肠炎小鼠中,BM治疗降低了疾病活动指数,直肠出血,组织学损伤和改善了肠道透性.
- BM减轻了氧化应激,保持了屏障完整性,抑制了炎症,并在暴露于DSS的Caco-2细胞中促进了自.
结论:
- 发酵甜菜汁 (BM) 显示出协同作用的抗氧化,抗炎和屏障保护作用.
- 乳腺癌显示出作为性结肠炎的饮食干预措施的显著治疗潜力.
- 这些发现表明,BM的好处超出了其单个成分,贝塔宁和莱文的范围.
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