作为HMGB1抑制剂的G-四方体形成性胺体的共价连接二元体

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Updated: Jun 30, 2026

Primer-Free Aptamer Selection Using A Random DNA Library
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Primer-Free Aptamer Selection Using A Random DNA Library

Published on: July 26, 2010

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Andrea Criscuolo1, Ettore Napolitano1, Claudia Riccardi1

  • 1Department of Chemical Sciences, University of Naples Federico II, via Cintia 21, 80126, Napoli, Italy.

International journal of biological macromolecules
|October 24, 2025
PubMed
概括

研究人员开发了L12合体的新型共价二分体,以抑制高流动性组盒1 (HMGB1). 最好的二元体,L12d1T3,有效地阻止HMGB1诱导的细胞迁移,显示出治疗炎症性疾病和癌症的希望.

关键词:
亚博体育官网 亚博体育官网 亚博体育官网 亚博体育官网 亚博体育官网变质化变质化 (Dimerization Dimerization) 是一种变质化的过程.在G-quadruplex结构中.这就是HMGB1的特点.它与蛋白质结合和抑制.

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