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在患有单边内动脉缩狭窄症的患者中,与认知障碍相关的淋巴功能障碍

Huihong Ke¹, Wansi Zhong¹, Chengjia Liu¹

¹From the Department of Neurology (H.K., W.Z., Y.Z., Y.H., Y.L., M.W., Z.Z., X.Z., M.L.), and Department of Radiology (C.L., J.S.), the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.

AJNR. American journal of neuroradiology

|October 24, 2025

概括

淋巴功能障碍与内动脉硬化狭窄症 (ICAS) 患者的认知能力下降有关. 狭窄症的严重程度恶化与淋巴功能受损相关,可能导致认知障碍.

科学领域:

神经学神经学
神经成像是一种神经成像.
脑血管疾病脑血管疾病

背景情况:

淋巴系统功能障碍与认知障碍有关.
它在单边内动脉样硬化狭窄症 (ICAS) 中的作用仍未得到充分研究.
ICAS会影响大脑血液流动,并可能导致神经系统缺陷.

研究的目的:

在单边ICAS患者中调查狭窄症严重程度和淋巴功能之间的关系.
探索淋巴管功能障碍对这一群体认知表现的影响.
确定淋巴功能是否调解了狭窄和认知障碍之间的联系.

主要方法:

招募了141名单边ICAS患者 (≥50%的狭窄) 和282名对照患者.
所有参与者都接受了MRI和神经心理测试.
用扩散张力成像沿周围血管空间 (DTI-ALPS) 指数评估淋巴功能.

主要成果:

与对照组相比,ICAS患者的全球和特定领域认知得分较低.
在ICAS患者中,ipsilateral和contralateral ALPS指数均降低.
下降的ipsilateral ALPS指数与增加的狭窄症严重程度和中介性认知衰退相关,特别是在执行功能中.

结论:

单边ICAS与淋巴管功能障碍有关,这与狭窄症的严重程度相关.
这种淋巴管损伤可能导致ICAS患者观察到的认知缺陷.
向淋巴系统可能为ICAS患者提供一种新的治疗策略.

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