创伤后压力和遗传相互作用影响创伤后的烟草和酒精使用:来自多祖先队列的发现
Henri M Garrison-Desany1, Cecilia A Hinojosa2, Justin D Tubbs3,4,5
1Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA. mgarris7@jhu.edu.
Translational psychiatry
|October 24, 2025
概括
遗传倾向和创伤后应激障碍 (PTSD) 症状相互作用,影响创伤后的烟草使用. 较低的遗传风险放大了PTSD症状和吸烟之间的联系,表明复杂的基因环境相互作用.
科学领域:
- 行为遗传学 行为遗传学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 烟草和酒精的使用是常见的,受遗传和环境的影响.
- 创伤事件非常普遍,影响到70%的个人.
- 创伤后应激障碍 (PTSD) 症状在创伤后物质使用中的作用,考虑到遗传风险,尚未完全理解.
研究的目的:
- 调查遗传风险得分 (PRS-CSx) 和PTSD症状在预测创伤后烟草和酒精使用之间的相互作用.
- 检查遗传倾向如何改变PTSD症状集群和物质使用行为之间的关联.
主要方法:
- 利用来自急诊室的2973名参与者在创伤后恢复的先进理解 (AURORA) 研究中的数据.
- 在创伤后8周和6个月评估PTSD症状 (DSM-5的PTSD检查清单) 和物质使用 (烟草,酒精).
- 生成了多基因风险评分 (PRS-CSx) 并使用准平衡回归来测试PRS-CSx和PTSD症状之间的主要影响和相互作用.
主要成果:
- 较高的烟草多基因风险评分 (PRS-CSx) 与使用烟草风险增加14%有关.
- 在欧洲祖先分队中,烟草和酒精PRS-CSx得分都显著预测了他们各自的物质使用.
- 观察到一种对抗性相互作用:较低的遗传风险放大了PTSD重新体验和烟草使用的认知/情绪症状之间的关联,而较高的遗传风险削弱了它.
结论:
- 遗传倾向在创伤事件后的物质使用行为中起着重要作用.
- 创伤后应激障碍症状与吸烟之间的关系是由个人的遗传风险调节的.
- 研究结果突出了复杂的基因环境相互作用,影响创伤后物质使用脆弱性,特别是烟草.
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