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Updated: Jan 14, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
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Published on: August 27, 2013

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霍泰尔需要表表体转录组修饰来发挥其在表皮细胞转移到介质细胞转变中的关键表观遗传作用

Sabrina Garbo1, Sara Minotti1, Francesco Marocco1

  • 1Department of Molecular Medicine, Department of Excellence 2023-2027, Sapienza University of Rome, Rome, Italy.

Cell death & disease
|October 24, 2025
PubMed
概括

这项研究揭示了N6-甲基氨酸 (m6A) 修饰对于长非编码RNAHOTAIR的表观遗传功能至关重要. 这种表皮转录组修饰调节了HOTAIR,SNAIL和EZH2之间的相互作用,从而控制了表皮细胞转化为介质细胞转化 (EMT).

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