阿克尔曼西亚菌 (Akkermansia muciniphila MucT) 利用食中的多类作为光体,增强铁的吸收
Maria-Carolina Rodríguez-Daza1, Sjef Boeren2, Hanne L P Tytgat1,3
1Laboratory of Microbiology, Wageningen University & Research, Stippeneng 4, WE, Wageningen, The Netherlands.
Nature communications
|October 24, 2025
概括
饮食中的益西安丁 (PACs) 通过选择性地食Akkermansia muciniphila,促进肠道健康. 这些化合物为有益的细菌提供铁,增强其生长和功能.
科学领域:
- 微生物组研究的研究.
- 营养生物化学 营养生物化学
- 肠道健康 肠道健康
背景情况:
- 饮食中含有的益阳氨酸 (PAC) 是一种已知影响肠道微生物群的多.
- PACs具有结合铁的甲基醇分类,可能会影响病原体和宿主铁的可用性.
- PACs选择性地促进了Akkermansia muciniphila的生长,这是一个有益的肠道共生体.
研究的目的:
- 阐明Akkermansia muciniphila通过饮食中的益西安丁 (PACs) 获取铁的机制.
- 研究铁含量高的PACs在支持A. muciniphila生长和代谢活动中的作用.
- 确定参与A. muciniphila.铁获取和 siderophore吸收调节的新信号通路.
主要方法:
- 综合性蛋白质组学和转录组学被用来分析A. muciniphila对PACs的反应.
- 研究了铁吸收系统,包括 siderophore 中介运输和铁铁运输器.
- 增长试验是使用含铁的PACs在贫铁介质中进行的.
主要成果:
- A. muciniphila 采用甲基醇类型的 siderophore 系统从 PAC 吸收 Fe3+,其中涉及 ATP 结合盒载体和 lipocalins.
- 铁2+载体的表达,吸收和铁储存蛋白的表达得到了上调.
- 含铁量高的PAC在缺乏铁的条件下恢复了A. muciniphila的生长,这表明它们被认定为异类生物.
结论:
- 饮食中的PAC通过新的获取机制为A. muciniphila提供铁的来源.
- PACs增强了A. muciniphila的新陈代谢活动和对铁稀缺的抵御力.
- 了解这些相互作用可以揭示饮食成分如何选择性地促进有益的肠道细菌,并可能抑制病原体.
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