保护隔膜软骨的早期修订:一个本病理学研究
Deniz Hancı1, Ömer Kumaş2, Hüseyin Turgut1
1Department of Otorhinolaryngology, University of Health Sciences, Prof. Dr. Cemil Taşcıoğlu City Hospital, Istanbul, Turkey.
概括
隔膜软骨在-20°C的干燥储存为修复鼻膜整形提供了最佳的长期可行性. 这种具有成本效益的方法比其他测试条件更好地保持了移植完整性.
科学领域:
- 整形外科 整形外科 整形外科
- 再生医学是一种再生医学.
- 历史学 历史学 历史学
背景情况:
- 自主隔膜软骨对于修改鼻膜整形术至关重要.
- 需要最佳的储存方法来保持随着时间的推移的移植活力.
- 之前的研究还没有全面评估存储介质和温度的影响.
研究的目的:
- 评估不同储存介质和温度对自身隔膜软骨组织学活力的影响.
- 为了确定最佳的储存条件,以保持修复鼻美术的软骨完整性.
主要方法:
- 来自30名患者的480个隔膜软骨样本被存储了6个月和12个月.
- 储存条件包括干燥, gentamicin, cefazolin 和盐水介质在-20°C和-80°C.
- 组织病理学评估评估了移植的活力,纤维化,骨形转化症和冠状腺增殖.
主要成果:
- 整体移植活力从6个月后的62%下降到12个月后的44% (p < 0.001).
- 在 -80°C和盐水中储存,与 -20°C的干燥储存相比,导致变质明显更快.
- 在-20°C的干燥储存表明最有利的长期可行性.
结论:
- 在-20°C的干燥储存是一种可行的,具有成本效益的方法,用于保存用于早期修复鼻美术的自身隔膜软骨.
- 建议进行进一步的前性临床试验,以验证这些发现.
- 抗生素添加剂不能防止生命力丧失.
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