基于手术的多式疗法在HPV阴性晚期HSCC中优于单独的化疗和放射治疗:T3/N2-3下甲状腺状细胞癌的优异结果
Xintong Chen1, Xiaoming Guo2, Shiping Liu2
1Department of Radiation Oncology, the First Hospital of China Medical University, No.155 Nanjing North Street, Shenyang, 110001, Liaoning, China.
概括
人类乳头瘤病毒 (HPV) 状态会影响下甲状腺状细胞癌 (HSCC) 治疗. 阴性HPVHSCC患者可以从手术与化疗疗相结合中获益,特别是在晚期.
科学领域:
- 在瘤学瘤学.
- 头部和部癌症研究研究
- 病毒瘤学 病毒瘤学
背景情况:
- 低甲状腺状细胞癌 (HSCC) 的治疗策略各不相同.
- 人类乳头瘤病毒 (HPV) 状态是已知的头癌的预后因素.
- HPV 在指导 HSCC 治疗选择中的作用需要进一步研究.
研究的目的:
- 为了确定HPV状态是否会影响HSCC的治疗决策.
- 为了比较HPV阳性和HPV阴性HSCC患者接受不同治疗方式的生存结果.
- 根据HPV状况,评估手术加化学放射治疗与单独化学放射治疗的疗效.
主要方法:
- 利用了来自监测,流行病学和最终结果 (SEER) 数据库的数据.
- 员工倾向分数匹配 (PSM) 用于队列平衡.
- 进行多变量考克斯回归和卡普兰-梅尔分析以评估生存率.
主要成果:
- 阳性HPVHSCC患者的癌症特异性存活率 (CSS) 和整体存活率 (OS) 显著改善.
- 手术显著改善了HPV阴性患者的CSS和OS,特别是T3和N2-3阶段疾病患者.
- 在不同阶段的HPV阳性HSCC患者中,没有观察到手术对生存的显著益处.
结论:
- 结合化疗和放射性疗法的手术是HPV阴性HSCC患者的更合适的治疗方法,患者患有T3阶段和N2-3阶段的疾病.
- HPV 状态是个性化 HSCC 治疗策略的关键因素.
- 进一步的研究可能会根据HSCC的HPV状况完善治疗方案.
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