糖或葡萄糖与母乳相比用于早产婴儿疼痛控制:系统性审查和元分析
Shaneela Shahid1,2, Jorge Acosta-Reyes3, Ivan D Florez4,5,6
1Department of Health Research Methods Evidence and Impact, McMaster University, Hamilton, ON, Canada.
概括
糖或葡萄糖 (SG) 在痛苦的手术过程中有效地减少了早产婴儿的哭泣时间. 然而,在减少疼痛强度方面,SG没有表现出优于母乳或奶 (BM/EBM) 的优势.
科学领域:
- 新生儿护理 新生儿护理
- 在婴儿的疼痛管理.
- 基于证据的实践实践.
背景情况:
- 过早出生的婴儿在常见的手术中会感到疼痛,比如脚和静脉穿刺.
- 有效的疼痛管理策略对于早产新生儿的福祉至关重要.
- 口服的糖糖或葡萄糖 (SG) 通常用于婴儿的手术疼痛缓解.
研究的目的:
- 系统地审查和元分析随机临床试验 (RCT) 关于SG与母乳或缩母乳 (BM / EBM) 对早产婴儿疼痛控制和哭泣持续时间的疗效.
- 为了比较SG和BM/EBM在降低脚跟穿刺和静脉穿刺手术期间疼痛强度和哭泣时间的有效性.
- 为了评估SG和BM/EBM干预之间的心率变化和不良事件的差异.
主要方法:
- 六项随机临床试验 (RCT) 的系统审查和元分析.
- 包括525名早产婴儿经历了脚穿刺或静脉穿刺.
- 糖 (24%) 或葡萄糖 (10-30%) 与母乳或奶 (BM/EBM) 的干预比较.
主要成果:
- 在手术后30秒 (早产婴儿疼痛概况得分) 中,在SG和BM/EBM (低确定性证据) 之间,没有发现疼痛减轻的显著差异.
- 与BM/EBM (中度确定性证据) 相比,糖或葡萄糖 (SG) 显著减少了哭泣时间.
- 两组之间没有观察到心率变化或不良事件的差异.
结论:
- 中等确定性证据表明,在早产婴儿的痛苦手术期间,SG可能比BM/EBM更有效地减少哭泣时间.
- 在通过PIPP/PIPP-R得分来衡量疼痛强度方面,SG没有显示出优于BM/EBM的优势.
- 可能需要进一步的研究,以充分阐明SG和BM/EBM在早产新生儿疼痛管理方面的比较有效性.
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