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Updated: Jun 21, 2026

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使用RNA-seq检测多发性骨髓瘤中的MRD:高灵敏度和预后值

Yuyue Ren1, Ming Liu2, Jiancheng Fang2

  • 1Department of Hematopathology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.

Cancer gene therapy
|October 24, 2025
PubMed
概括

与向DNA测序相比,RNA测序 (RNA-seq) 提供了一种更敏感的方法来监测多发性骨髓瘤 (MM) 患者的最小残留疾病 (MRD). 这种方法有助于通过检测克隆免疫球蛋白基因表达来预测患者的预后.

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相关概念视频

RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...