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计算机认知训练通过降低Ruminococcus-TMAO通路的调节来增强阿尔茨海默氏症患者的认知功能.

Wenbo Zhang1, Jiaqi Song2, Fuxin Zhong1

  • 1Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.

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概括

计算机认知训练 (CCT) 改善了轻度阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的认知. 通过降低R扭矩和TMAO水平,CCT可能会准微生物群-肠-大脑轴.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.计算机化认知训练是计算机化的认知训练.功能性近红外光谱学近红外光谱学我们的肠道微生物群.微生物群-肠道-大脑轴

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科学领域:

  • 神经科学是一个神经科学.
  • 微生物学 微生物学
  • 胃肠病学 胃肠病学

背景情况:

  • 微生物群-肠-大脑 (MGB) 轴因其在阿尔茨海默病 (AD) 发病过程中的作用越来越受认可.
  • 然而,针对AD的MGB轴的有效干预策略仍然有限.

研究的目的:

  • 研究计算机化认知训练 (CCT) 在轻度认知障碍 (MCI) 或轻度AD患者的疗效.
  • 探索CCT对认知功能,功能连接和MGB轴的影响,包括肠道微生物群和血三甲基胺N氧化物 (TMAO) 水平.

主要方法:

  • 一项为期24周的单盲随机对照试验,涉及84名患有MCI或轻度AD的参与者.
  • 参与者接受了CCT或通常治疗 (TAU).
  • 结果包括认知评估 (ADAS-cog),功能连接 (fNIRS),血TMAO和肠道微生物群分析.

主要成果:

  • 与TAU相比,CCT显著改善了认知功能 (ADAS-cog分数).
  • CCT导致前额功能连接的变化,并降低了血TMAO水平.
  • CCT缓解了Ruminococcus torques (R. torques) 的扩张,这种肠道细菌与认知和生物标志物变化相关.

结论:

  • 24周的CCT计划可以提高MCI和轻度AD的认知功能.
  • 这些发现表明,CCT可能通过MGB轴作用,特别是通过下调R.扭矩-TMAO路径.
  • 这一途径为阿尔茨海默病的多领域干预提供了潜在的治疗目标.