计算机认知训练通过降低Ruminococcus-TMAO通路的调节来增强阿尔茨海默氏症患者的认知功能
Wenbo Zhang1, Jiaqi Song2, Fuxin Zhong1
1Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, China.
Journal of translational medicine
|October 24, 2025
概括
计算机认知训练 (CCT) 改善了轻度阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的认知. 通过降低R扭矩和TMAO水平,CCT可能会准微生物群-肠-大脑轴.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 微生物群-肠-大脑 (MGB) 轴因其在阿尔茨海默病 (AD) 发病过程中的作用越来越受认可.
- 然而,针对AD的MGB轴的有效干预策略仍然有限.
研究的目的:
- 研究计算机化认知训练 (CCT) 在轻度认知障碍 (MCI) 或轻度AD患者的疗效.
- 探索CCT对认知功能,功能连接和MGB轴的影响,包括肠道微生物群和血三甲基胺N氧化物 (TMAO) 水平.
主要方法:
- 一项为期24周的单盲随机对照试验,涉及84名患有MCI或轻度AD的参与者.
- 参与者接受了CCT或通常治疗 (TAU).
- 结果包括认知评估 (ADAS-cog),功能连接 (fNIRS),血TMAO和肠道微生物群分析.
主要成果:
- 与TAU相比,CCT显著改善了认知功能 (ADAS-cog分数).
- CCT导致前额功能连接的变化,并降低了血TMAO水平.
- CCT缓解了Ruminococcus torques (R. torques) 的扩张,这种肠道细菌与认知和生物标志物变化相关.
结论:
- 24周的CCT计划可以提高MCI和轻度AD的认知功能.
- 这些发现表明,CCT可能通过MGB轴作用,特别是通过下调R.扭矩-TMAO路径.
- 这一途径为阿尔茨海默病的多领域干预提供了潜在的治疗目标.
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