克隆性血液形成中的种族差异及其对血液性恶性瘤的影响
Zijian Zhang1,2,3, Chao Cheng4,5,6
1Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, Texas, USA.
Journal of hematology & oncology
|October 25, 2025
概括
不确定潜力的克隆性血液形成 (CHIP) 在流行率和突变模式上显示了种族差异. CHIP增加了血液性恶性瘤的风险,祖先影响了特定的骨髓性恶性瘤亚型.
科学领域:
- 血液学 血液学 血液学
- 遗传学 遗传学 是一个
- 在瘤学瘤学.
背景情况:
- 不确定潜力的克隆性血液形成 (CHIP) 是已知的血液恶性瘤 (HM) 的风险因素.
- 关于CHIP分布和跨不同祖先的临床影响的数据有限.
- 了解这些差异对于风险评估和预防至关重要.
研究的目的:
- 调查CHIP患病率,突变特征和HM的进展在一个大规模的,种族多样化的队列中.
- 确定CHIP生物学中的种族差异及其与特定HM亚型的关联.
- 强调在CHIP研究和临床实践中需要基于祖先的方法.
主要方法:
- 来自我们所有人研究计划的大型队列 (245,388名参与者) 的分析.
- 在9,476个个体中识别CHIP驱动突变.
- 跨种族群体对CHIP流行,突变模式和HM风险的比较分析.
主要成果:
- 确定了10,446种CHIP驱动突变.
- 与白人美国人 (WA) 个人相比,非洲裔美国人 (AA) 个体表现出更高的CHIP流行率和明显的突变模式.
- CHIP与增加的HM风险有关,特别是骨髓性恶性瘤,祖先影响了特定的亚型,如骨髓增殖性瘤.
结论:
- 在CHIP生物学和HM进展方面存在显著的种族差异.
- 祖先是理解CHIP相关的HM风险和亚型的关键因素.
- 对于有效的CHIP风险分层和HM预防,需要基于祖先的策略.
相关概念视频
Hematopoiesis
8.7K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.7K
Disorders of Leukocytes
1.8K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.8K
Regulation of Hematopoietic Stem Cells
3.9K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.9K
Bone Marrow Sampling and Transplants
876
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
876
Lineage Commitment
4.1K
Commitment is the process whereby stem cells:
4.1K
Role of Hematopoietic Growth Factors
3.1K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
3.1K


