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饮食炎症指数和COPD之间的J形关联:从NHANES 1999年到2018年的横截面研究
Tulei Tian1, Jing Xia1, Hongbo Zhang1
1Department of Respiratory and Critical Care Medicine, the Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, China.
通过饮食炎症指数 (DII) 测量的促炎症饮食与美国成年人患慢性阻塞性肺病 (COPD) 的风险更高有关. 该关联显示了一个J形曲线,表明COPD的可能性增加,DII得分高于某个值.
科学领域:
- 营养科学 营养科学
- 肺部病理学 肺部病理学
- 公共卫生 公共卫生
背景情况:
- 炎症在慢性阻塞性肺病 (COPD) 的发展中起着关键作用.
- 针对炎症的饮食修改可以帮助COPD管理.
- 在美国一般成年人群中,饮食炎症潜力和COPD之间的关系仍未得到充分研究.
研究的目的:
- 为了研究饮食的炎症潜力之间的联系,通过饮食炎症指数 (DII) 量化,在美国成年人群中研究COPD.
- 分析剂量反应关系并确定任何值效应.
主要方法:
- 利用了从国家健康和营养检查调查 (NHANES) 覆盖1999-2018年的数据.
- 采用多因素物流回归,曲线拟合和值效应分析.
- 包括39,195名成年参与者,COPD是依赖变量,DII是独立变量.
主要成果:
- 在对混因子进行调整后 (OR=1.05) 观察到DII和COPD之间存在正相关性.
- 在最高的DII第三层 (T3) 个体中,与最低的第三层 (T1) 相比,COPD患病的可能性高出23%.
- 在DII和COPD之间发现了J形关联,在DII值为2.71 (OR=1.268) 之后出现了显著的正相关性.
结论:
- 该研究表明,在美国成年人的全国代表样本中,饮食炎症潜力和COPD之间存在J形关联.
- 较高的DII分数,表明一种更有利于炎症的饮食,与COPD的风险增加有关.
- 这些发现凸显了饮食对COPD风险的潜在影响,并表明了特定的饮食值,超过这个值后,风险显著增加.
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