阶段角度作为一种预测标记,用于新诊断的2型糖尿病中非常低热量饮食的有效性
Yanjing Fan1, Tianchi Hu, Yi Zhou
1Department of Endocrinology, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, Fujian Province, China.
Medicine
|October 25, 2025
概括
阶段角度 (PhA) 预测了新型2型糖尿病患者在非常低热量饮食 (VLCD) 上的治疗成功. 较低的PhA表明预后较差,特别是在男性中,这表明它可以作为VLCD疗效的早期生物标志物.
科学领域:
- 生物医学科学 生物医学科学
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 阶段角 (PhA) 表示细胞膜完整性和细胞功能.
- PhA可以预测新诊断的2型糖尿病 (T2DM) 患者的预后,这些患者接受非常低热量饮食 (VLCD).
研究的目的:
- 调查生物电阻PhA对T2DM中VLCD治疗疗效的预测值.
- 探索PhA作为VLCD后代谢改善的早期生物标志物.
主要方法:
- 223名新诊断的T2DM患者接受了为期9天的VLCD干预.
- 基线PhA通过多频生物电阻分析测量.
- 治疗疗效定义为治疗后HOMA-IR<2.5;使用后勤回归和ROC曲线进行分析.
主要成果:
- 62.3%的患者获得治疗效果,体重和血糖指标得到改善.
- 在男性 (OR=6.34) 和女性 (OR=1.82) 中,PhA是一个独立的预测因子.
- ROC分析显示男性的最佳预测准确度 (AUC=0.728),女性的预测值有限 (AUC=0.586).
结论:
- 降低的PhA是VLCDT2DM患者预后的一个危险因素.
- PhA可以作为VLCD疗效的预测指标,特别是在男性T2DM患者中.
- PhA在评估VLCD干预结果方面具有潜在的临床应用价值.
相关概念视频
Carbohydrate Metabolism
13.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.8K
Diabetes: Management and Pharmacotherapy
861
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
861
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Oral Hypoglycemic Agents: Biguanides and Glitazones
582
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
582
Diabetes Mellitus: Overview and Type I Subtype
4.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.9K


