甲状腺抗体状况,甲状腺功能,以及冠状动脉疾病和中风风险:从14个队伍中进行个体参与者数据分析
Ola Hysaj1,2, Orestis Efthimiou1, Tinh-Hai Collet3,4
1Institute of Primary Health Care (BIHAM), University of Bern, 3012 Bern, Switzerland.
European journal of endocrinology
|October 25, 2025
概括
甲状腺过氧化酶抗体 (TPOAb) 状态不会增加心血管疾病风险,即使在亚临床甲状腺功能低下症患者中也是如此. 不建议对TPOAb进行测试,以评估心血管风险.
科学领域:
- 内分泌学和免疫学.
- 心血管流行病学心血管流行病学
背景情况:
- 甲状腺过氧化酶抗体 (TPOAb) 与心血管疾病 (CVD) 风险之间的关系,独立于甲状腺功能,尚未得到充分证实.
- 了解这种关联对于准确的心血管疾病风险分层至关重要.
研究的目的:
- 调查TPOAb阳性状态与心血管疾病风险之间的关联.
- 确定TPOAb阳性是否会增加亚临床甲状腺功能低下症患者心血管疾病风险.
主要方法:
- 对14项队列研究进行了两阶段的个人参与者数据分析.
- 主要结局包括冠心病 (CHD) 事件/死亡率和中风事件/死亡率.
- 使用了Cox比例危险模型和随机效应元分析,根据年龄,性别和TSH进行调整.
主要成果:
- 在100,250名成年人中,TPOAb阳性个体 (11.9%) 与TPOAb阴性个体相比没有增加心血管疾病事件,心血管疾病死亡率,中风事件或中风死亡率的风险.
- 在患有亚临床甲状腺功能低下症 (5.4%) 的患者中,TPOAb阳性也与任何心脏病结局的更高风险无关.
结论:
- 阳性TPOAb状态与冠状动脉疾病或中风的风险增加无关.
- 目前的研究结果不支持在一般人群或患有亚临床甲状腺功能低下症的人群中使用TPOAb测试进行心血管风险评估.
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