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量化方法加速MASH药物发现和开发

Yasmeen Abouelhassan1, Shailendra Tallapaka1, Ramin Mehrani1

  • 1Department of Quantitative Pharmacology and Pharmacometrics, Merck & Co., Inc., Rahway, New Jersey, USA.

Clinical pharmacology and therapeutics
|October 25, 2025
PubMed
概括

基于模型的药物发现加速了对代谢功能障碍相关的脂肪肝炎 (MASH) 治疗方法的开发. 像QSP,MBMA和AI/ML这样的定量方法可以提高MASH疗法的临床试验效率和生物标志物解释.

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