相关实验视频

Updated: Jan 14, 2026

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

Creation and Transplantation of an Adipose-derived Stem Cell ASC Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

灵感来自介酶体干细胞的微针平台,用于NIR响应性免疫调节和加速慢性伤口愈合

Chan Ho Moon¹, Hee Gyeong Ko^2,3, Hyun Lee⁴

¹Division of Materials Science and Engineering, Hanyang University, Seoul, 04763, Republic of Korea.

Advanced materials (Deerfield Beach, Fla.)

|October 25, 2025

概括

一种新型的微针平台为糖尿病伤口提供介质干细胞外体,减少炎症并促进愈合. 这种仿生方法增强了血管生成和皮肤再生,用于慢性伤口治疗.

科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
伤口愈合治愈伤口愈合

背景情况:

慢性糖尿病伤口由于持续的炎症和不良愈合,造成了重大的临床挑战.
介酶干细胞 (MSCs) 分泌外体,调节组织微环境进行再生.

研究的目的:

开发一个仿生微针 (MSCi@MN) 平台,用于增强慢性糖尿病伤口治疗.
利用MSC衍生的外体和向药物输送来改善治疗结果.

主要方法:

制造一个双隔间微针平台,其中包含MSC衍生的纳米丝与聚二氧化碳核酸 (NV-DNA) 和MXene纳米粒子结合.
利用近红外 (NIR) 辐射来控制NV-DNA的释放和光热特性的激活.
在糖尿病动物模型中研究了免疫调节效应,转录基因变化和伤口愈合疗效.

主要成果:

MSCi@MN促进了M2巨细胞的两极分化,并激活了耐受性树突细胞,创造了一个再生的微环境.
转录组分析证实NV-DNA促进了血管生成,增殖和细胞外矩阵重塑.
在糖尿病模型中,MSCi@MN显著加快了伤口修复,减少了炎症,增强了血管生成,并恢复了皮肤附属物,没有任何不良影响.

结论:

受MSC启发的微针平台为慢性伤口管理提供了一个有前途的战略.
这种方法将受控释放与强大的免疫再生能力相结合,用于先进的再生医学应用.

关键词:

生物启发的生物启发.慢性伤口愈合慢性伤口愈合中介细胞干细胞中介细胞干细胞.微针微针是一种微针.接近红外的响应能力强.

更多相关视频

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion

Published on: May 10, 2020

相关概念视频

Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

Tissue Renewal without Stem Cells

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

Stem Cell Therapy for Tissue Regeneration

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...