血管细胞粘附分子1:对心房动和心力衰竭风险的标志物
Jonas Alexander Baadsgaard1,2, Oliver Bundgaard Vad1,2, August Krebs Hessellund1
1Department of Cardiology, The Heart Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
概括
升高的可溶性血管细胞粘附分子1 (sVCAM-1) 与心房动 (AF) 和心力衰竭 (HF) 的风险增加有关. 将sVCAM-1与遗传风险得分相结合,可以提高AF风险预测.
科学领域:
- 心血管医学 心血管医学
- 生物标志物发现发现
- 遗传学 遗传学 是一个
背景情况:
- 可溶性血管细胞粘附分子1 (sVCAM-1) 是心血管疾病的潜在生物标志物.
- 前庭动 (AF) 和心力衰竭 (HF) 是重大的公共卫生问题.
- 遗传倾向在AF的发展中起着重要作用.
研究的目的:
- 调查sVCAM-1水平与发生AF和HF风险之间的关联.
- 评估sVCAM-1和AF多基因风险评分 (PRS) 对AF的综合预测值.
- 探索sVCAM-1与心脏结构/功能之间的关系.
主要方法:
- 利用了来自48495名参与者的英国生物库数据 (2006-2023年).
- 使用考克斯比例危险回归来评估sVCAM-1与AF和HF发病率的关联.
- 通过AF PRS和sVCAM-1三位体进行分层分析;在子队列中评估心脏MRI测量.
主要成果:
- 较高的sVCAM-1水平与AF (HR: 1.72) 和HF (HR: 2.04) 的风险增加有显著的相关性.
- 在sVCAM-1,AF PRS和AF风险之间观察到剂量反应关系.
- 在心脏成像子队列中,升高的sVCAM-1与左心房喷射率 (LAEF) 的降低有关.
结论:
- sVCAM-1是AF和HF风险的重要预测因素.
- 将sVCAM-1与AF PRS集成,可以更好地识别面临AF高风险的个体.
- sVCAM-1可能反映了潜在的心脏功能障碍,有助于AF和HF的发展.
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