我们是否准备好预防1型糖尿病?
Evelina Maines1, Roberto Franceschi2, Francesca di Candia3
1Department of Pediatrics, S. Chiara Hospital of Trento, APSS, Trento, Italy.
Diabetes/metabolism research and reviews
|October 25, 2025
概括
预防1型糖尿病 (T1D) 正在通过新的疾病修饰疗法取得进展. 虽然teplizumab延迟了T1D第3阶段的发病,但研究仍在继续优化阻止β细胞破坏的治疗方法.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 预防1型糖尿病 (T1D) 仍然是一个挑战,但疾病修饰疗法提供了新的希望.
- 了解T1D进展对于开发有效的干预措施至关重要.
研究的目的:
- 通过修改疾病的疗法,审查当前关于青少年T1D预防的知识.
- 总结针对T1D不同阶段的治疗方法.
主要方法:
- 进行了叙事文学评论.
- 使用关键词搜索了PubMed/MEDLINE数据库:"查"",预防"",疾病修饰疗法"和"年轻人 (0-18岁) 的1型糖尿病".
主要成果:
- 德普利祖马布是第一个FDA批准的药物,可以延迟T1D第3阶段的发病.
- 目前正在研究各种药物 (单克隆抗体,细胞因子抑制剂,抗原特异性疗法).
- 第三阶段T1D的干预措施显示暂时改善β细胞功能,但好处是短暂的.
结论:
- 疾病修饰疗法代表了T1D管理的新时代,旨在阻止进展.
- 进一步的研究对于完善患者选择,确定新点,优化免疫治疗时间和耐久性至关重要.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Diabetes Mellitus: Overview and Type I Subtype
4.9K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.9K
Diabetes: Management and Pharmacotherapy
861
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
861
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Carbohydrate Metabolism
13.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.8K
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K


