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Updated: Jan 14, 2026

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
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通过贝叶斯剂量响应模型改善模型辅助设计的I期试验的最大耐受剂量选择

Rentaro Wakayama1, Tomotaka Momozaki2, Shuji Ando2

  • 1Department of Information Sciences, Graduate School of Science and Technology, Tokyo University of Science, Chiba, Japan.

Pharmaceutical statistics
|October 25, 2025
PubMed
概括

这项研究引入了一种新的贝叶斯剂量-反应模型,用于在早期瘤学试验中确定最大耐受剂量 (MTD). 这种新方法通过提供更稳定的毒性估计来提高MTD选择准确性和试验效率.

关键词:
贝叶斯的推理 贝叶斯的推理贝叶斯的最佳间隔设计.发现剂量发现剂量同位素回归的同位素回归最大的耐受剂量.

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