区分肥胖在不同生命阶段对人类寿命和衰老的影响
Pei Xiao1, Yan Li2, Jingfan Xiong2
1Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Mayo Clinic proceedings
|October 25, 2025
概括
儿童身体质量指数 (BMI) 显著影响长寿和衰老. 较高的儿童BMI与父母寿命缩短和加快衰老标志物有关,这强调了早期体重管理对长期健康的重要性.
科学领域:
- 遗传学和衰老研究研究
- 生命历程流行病学 流行病学
- 公共卫生与营养
背景情况:
- 了解不同生命阶段的体重对健康的长期影响,对于公共健康至关重要.
- 以前的研究已经探索了成年人肥胖和衰老之间的联系,但早期体重对生命的独立影响仍然不太清楚.
研究的目的:
- 研究不同生命阶段的体重对人类寿命和衰老结果的独立因果关系.
- 为了区分出生体重,儿童体重指数 (BMI) 和成年BMI对衰老的影响.
主要方法:
- 采用一生历程的门德尔随机化 (MR) 框架来分析遗传关联.
- 使用单变量和多变量MR来分别评估整体和独立的影响.
- 检查了不同生命阶段遗传预测的BMI与衰老结果 (如父母的寿命,预期寿命,表观遗传年龄加速,面部衰老和脆弱指数) 之间的关系.
主要成果:
- 基因预测的儿童高BMI与父母寿命缩短,寿命更低的几率以及加速的内在表观遗传年龄,面部衰老和脆弱性有关.
- 这些儿童BMI的关联在调整出生体重和成年BMI后仍然显著,除了面部衰老.
- 在所有灵敏度分析中,研究结果都很强大,证实了早期肥胖的独立影响.
结论:
- 儿童体重指数 (BMI) 对衰老和寿命有持久和独立的影响.
- 早期的脂肪在确定长期健康轨迹和衰老过程中起着至关重要的作用.
- 针对儿童体重管理的干预措施可能是促进健康衰老和寿命的关键.
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