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在异质造血干细胞移植前和之后的儿科骨髓微环境:一项多中心回顾性研究,比较捐赠者和接受者

Pan Zhang^1,2, Ang Wei^3,4,5,6,7, Guanghua Zhu^3,4,5,6,7

¹Department of Stem cell Transplantation, Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, 071000, China.

Annals of hematology

|October 25, 2025

概括

儿童骨髓比成人骨髓具有更好的造血干细胞再生和更少的氧化应激. 较低的内皮原生细胞比例与儿童在HSCT后的移植功能不佳有关.

科学领域:

血液学血液学血液学
儿科瘤学儿科瘤学
干细胞移植干细胞移植

背景情况:

骨髓微环境对于造血干细胞 (HSC) 功能至关重要.
儿科与成人骨髓微环境的差异尚未完全理解.
了解这些差异可能会影响儿科造血干细胞移植 (HSCT) 的结果.

研究的目的:

为了比较健康儿童和成人骨髓微环境.
研究HSCT后骨髓微环境与儿科HSCT接受者的移植功能之间的关联.

主要方法:

对儿科HSCT患者和健康的成年捐赠者的回顾性分析.
骨髓样本在HSCT前和之后 (14-90天) 进行分析.
测量了内皮原生细胞 (EPC),造血干细胞 (CD34+ HSC) 和活性氧物种 (ROS) 水平的百分比.

主要成果:

成年捐赠者比儿科捐赠者 (0-6岁) 的HSC比例较低,HSC-ROS水平较高.
具有良好的移植功能 (GGF) 的患者的EPC比例明显高于具有不良移植功能 (PGF) 的患者.
在HSCT后的EPC比例>0.071%预测了GGF (AUC=0.874).

结论:

与成人相比,儿童骨髓具有优越的造血再生能力和减少的氧化应激.
在HSCT后骨髓中较低比例的EPC与儿科患者的缺陷血液形成和PGF有关.

关键词:

骨髓的微环境骨髓的微环境内皮前代细胞是内皮前代细胞造血干细胞移植造血干细胞移植缺陷的移植功能缺陷的移植功能

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