在整体新辅助治疗直肠癌后的生活质量
Georg W Wurschi1,2,3, Markus Diefenhardt4,5, Justus Kaufmann6
1Department of Radiotherapy and Radiation Oncology, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany. georg.wurschi@med.uni-jena.de.
Journal of cancer research and clinical oncology
|October 25, 2025
概括
与一般人群相比,接受全新辅助疗法 (TNT) 的局部晚期直肠癌 (LARC) 患者报告了较低的健康相关生活质量 (HRQoL). 然而,他们的HRQoL与其他结直肠癌 (CRC) 患者相似,突出了持续毒性管理的必要性.
科学领域:
- 在瘤学瘤学.
- 临床研究 临床研究
- 患者报告的结果
背景情况:
- 总的新辅助疗法 (TNT) 越来越多地用于局部晚期直肠癌 (LARC).
- 评估与健康相关的生活质量 (HRQoL) 对于了解TNT的长期影响至关重要.
- 需要对一般和其他癌症群体进行比较的数据.
研究的目的:
- 为了评估TNT后LARC患者的HRQoL.
- 将HRQoL与德国普通人口进行比较.
- 为了将HRQoL与接受治疗治疗的结直肠癌 (CRC) 患者进行比较.
主要方法:
- 一个多中心的,横截面研究 (TNTox框架).
- EORTC QLQ-C30和QLQ-CR29问卷被用于TNT后的LARC患者.
- 对HRQoL得分与参考值和探索性分析进行描述性比较.
主要成果:
- 72名LARC患者完成了这项研究.
- 与一般人群相比,观察到显著降低HRQoL,特别是在角色和社会功能方面.
- HRQoL与治疗后的CRC患者相似,但便失禁,阳和失症的发病率更高.
- 慢性治疗毒性和TNT持续时间是影响HRQoL的重要因素.
结论:
- 与一般人群相比,接受TNT治疗的LARC患者的HRQoL有所降低.
- HRQoL结果与治疗治疗意图的CRC患者相似.
- 慢性毒性显著影响HRQoL,需要为幸存者量身定制的长期管理策略.
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