认知分散与粉素阳性老年人的白质过强度有关
Daliah Ross1, Fini Chang1,2, Lauren Edwards3
1Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
The Clinical neuropsychologist
|October 25, 2025
概括
认知变异性或个体内变异性分散与具有β-粉样蛋白阳性的人群中更多的白质超强度有关. 这表明,个体内可变性分散可能表明阿尔茨海默病的早期脑血管变化.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 认知科学 认知科学
背景情况:
- 白质高强度 (WMH) 是小血管脑血管疾病的标志物,与痴呆风险有关,包括阿尔茨海默病 (AD).
- 认知个体内变化 (IIV),特别是IIV分散,是未来认知衰退的新兴敏感指标.
- 了解IIV分散,β-粉样蛋白 (Aß) 状态和WMH之间的关系对于早期AD检测和干预至关重要.
研究的目的:
- 在没有痴呆症的老年人中,研究认知个体内可变性分散 (IIV分散),β-粉样蛋白 (Aß) 阳性和白质超强度 (WMH) 之间的关联.
- 确定Aß状态是否能缓和IIV分散和WMH之间的关系.
主要方法:
- 利用来自阿尔茨海默病神经成像计划的819名非痴呆症参与者的数据 (平均年龄72.01).
- 在六个神经心理测试中使用个体内标准偏差计算了IIV分散.
- 从T2加权流体减弱倒置恢复MRI扫描中量化WMH体积,并使用回归模型来分析相互作用,根据年龄,性别和教育进行调整.
主要成果:
- Aß状态显著缓解了IIV分散与WMH之间的关联.
- 在Aß阳性个体中,较高的IIV分散与较大的WMH有关,无论WMH是否被分析为连续变量 (B=0.30,p=0.006) 或二分法变量 (OR=2.41,p<0.001).
- 调整平均认知度的灵敏度分析证实,在Aß阳性个体中,较大的IIV分散与较大的WMH有关 (二分型WMH:OR=2.13,p=0.018),尽管连续WMH的影响减弱了.
结论:
- 增加的IIV分散与那些对β-粉样蛋白呈阳性的人群中更大的WMH负担有关.
- 在阿尔茨海默病的背景下,IIV分散可以作为脑血管变化的早期生物标志物.
- 需要进一步的研究来证实IIV分散在预测AD相关的脑血管病理方面的增量实用性.
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