牙周炎和妊娠糖尿病通过全身炎症之间的关联:一项前性队列研究
Jing Cheng1, Yun Tao2, Qian Gong1
1Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Journal of periodontology
|October 25, 2025
概括
严重的牙周炎显著增加妊娠糖尿病的风险,特别是在30岁以上的女性中. 系统性炎症部分解释了这种联系,突出了牙健康和怀孕时葡萄糖水平之间的联系.
科学领域:
- 产科和妇科 产科和妇科
- 牙周病学 牙周病学
- 内分泌学 在内分泌学.
背景情况:
- 牙周炎的严重程度和妊娠期糖尿病 (GDM) 风险之间的关联还不清楚.
- 关联牙周健康和GDM的生物学机制尚不清楚.
研究的目的:
- 调查牙周炎严重程度与GDM风险之间的关联.
- 探索系统性炎症作为调解途径的作用.
主要方法:
- 对446名孕妇 (12-20周妊娠期) 的前性研究.
- 用于评估关联的逻辑和线性回归模型.
- 根据年龄分层分析和通过炎症生物标志物的调解分析.
主要成果:
- GDM发病率为26.68%,随着牙周炎的严重程度而增加.
- 患有II-IV期牙周炎的女性的GDM风险增加了3倍 (OR=3.00).
- 这种关联在30岁以上的女性 (OR=4.78) 和患有I期牙周炎的女性 (OR=2.84) 中显著.
- 系统性炎症标志物部分介导了牙周炎-GDM联系 (11.71%-18.61%).
结论:
- 牙周炎的严重程度与剂量依赖,与30岁以上的孕妇的GDM风险增加有关.
- 系统性炎症部分调解了这种关联,这表明存在生物联系.
- 保持牙周健康对于在怀孕期间管理GDM风险可能很重要.
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