HoloSimR:用于模拟繁殖计划的综合框架,包括全基因组场景.
Cristina Casto-Rebollo1, Ivan Pocrnic2, Gregor Gorjanc2
1Institute for Animal Science and Technology, Universitat Politècnica de València, C/Camino de Vera s/n, València, 46022, Spain.
Journal of animal science
|October 25, 2025
概括
这项研究介绍了HoloSimR,这是一个R包,用于模拟畜牧养殖中宿主微生物群的共同进化. 它有助于研究人员了解微生物群对选择反应的影响,并开发新的育种策略.
科学领域:
- 动物繁殖 动物繁殖
- 微生物组研究的研究.
- 计算生物学是一种计算生物学.
背景情况:
- 将微生物组数据整合到畜牧养殖计划中可以增强选择反应.
- 微生物组的复杂性给多个物种和多个特征的建模带来了挑战.
- 准确估计微生物活性和物种识别在很大程度上取决于方法.
研究的目的:
- 开发一个R包,HoloSimR,用于模拟选择下的全基因组进化.
- 为了探索微生物群对表型选择反应的影响.
- 研究环境,宿主遗传和微生物对微生物群组成的共生影响.
主要方法:
- 开发了HoloSimR,这是一个模拟基因组和微生物群共同进化的R包.
- 综合基因,微生物群和基于全基因组的表型模型.
- 在实时数据结构的三个场景中,模拟了10代的分歧选择.
主要成果:
- 在复杂的模拟中,HoloSimR展示了强大的计算性能.
- 该包装准确地复制了真实的微生物分布,遗传性和物种间的相关性.
- 标准笔记本电脑上的模拟在68.42分钟内完成.
结论:
- HoloSimR是一个可扩展和强大的平台,用于在动物育种中进行in silico研究.
- 它促进了假设测试和开发新的育种方法.
- 该套餐促进了对宿主微生物群相互作用的理解,以改进畜牧养殖计划.
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