术治疗非小细胞肺癌的萨尔科佩尼亚和生存率:系统性审查和元分析
Troels Lading1, Ara Shwan Media1, Bertram Tellefsen2
1Department of Cardiothoracic & Vascular Surgery, Aarhus University Hospital, Aarhus, Denmark; Department of Biomedicine, Aarhus University, Aarhus, Denmark.
概括
肉,或肌肉损失,与非小细胞肺癌 (NSCLC) 患者接受手术的生存率较低有关. 这种关联在早期NSCLC中更为强烈.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 手术瘤学手术瘤学
背景情况:
- 肺癌是癌症死亡的主要原因之一.
- 手术切除是早期非小细胞肺癌 (NSCLC) 的治疗选择.
- 萨科佩尼亚是癌症存活率的一个新兴的负预后因素.
研究的目的:
- 系统地评估CT衍生的肉病与接受手术治疗的NSCLC患者的整体存活率之间的关联.
- 综合了关于手术治疗NSCLC患者的肉类和生存结果的现有文献中的证据.
主要方法:
- 在主要数据库 (PubMed,Embase,Scopus,Cochrane) 进行了全面的系统文献搜索.
- 包括了评估CT衍生的肉病与手术治疗NSCLC患者的整体存活率之间的联系的研究.
- 对符合条件的研究数据进行了元分析.
主要成果:
- 27项涉及12,011名患者的研究符合纳入标准.
- 1.99的综合危险比表明,与非sarcopenic患者相比,sarcopenic患者的死亡风险几乎是两倍的.
- 这种关联在早期病理阶段 (I-II) 更为明显,危险比为2.33.
结论:
- 在定义和测量肉类症的研究中存在方法异质性.
- 在手术治疗的NSCLC患者中,sarcopenia与整体存活率降低有关.
- 评估肌肉质量可能有价值在管理NSCLC患者,特别是在早期阶段.
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