运动在实验性牙周炎中调节局部炎症和组织损失:ra中的一个组织形态测量和免疫组织化学研究
Gümrükçüoğlu Zehra1, Burcu Özkan Çetinkaya1, Ferda Pamuk Özer2
1Ondokuz Mayıs University, Faculty of Dentistry, Department of Periodontology, Samsun 55200, Turkey.
Archives of oral biology
|October 25, 2025
概括
在患有牙周炎的老鼠中,抵抗运动显著降低了膜骨损失和附着损失. 运动还降低了TNF-α等炎症标志物,这表明运动对牙周病的进展起着保护作用.
科学领域:
- 牙周病学 牙周病学
- 运动生理学 运动生理学
- 口腔生物学 口腔生物学
背景情况:
- 牙周病是一种常见的炎症状况,影响牙支结构.
- 膜骨损失和附着损失是牙周病进展的关键指标.
- 炎症媒介和骨代谢标志物在疾病发病过程中起着至关重要的作用.
研究的目的:
- 为了评估抵抗运动对牙周病进展在老鼠模型的影响.
- 评估运动对膜骨损失,附着损失和炎症标志物的影响.
- 研究运动对骨代谢标记物的影响,包括RANKL/OPG.
主要方法:
- 40只雄性Wistar白色老鼠被分为四组,使用2x2的因数设计.
- 实施了为期八周的逐步游泳阻力炼方案.
- 进行了组形测量,免疫组织化学和行为测试 (MBT).
主要成果:
- 与没有运动的群体相比,运动的群体表现出明显较低的膜骨损失和附着损失.
- 瘤坏死因子-α (TNF-α) 的表达在经过运动的患有牙周炎的老鼠中显著降低.
- 核因子kappa-B连接体 (RANKL) 的受体激活体表达在一个不运动的组中升高,骨质保护素 (OPG) 没有显著变化.
结论:
- 抵抗运动在老鼠中显示出对牙周病进展的保护作用.
- 运动减少了促炎性细胞因子TNF-α,并显示了增加抗炎性IL-10的趋势.
- 研究结果表明,运动可以减轻牙周炎相关的行为变化,支持其辅助治疗潜力.
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