定义甲状腺切除术在转移性分化甲状腺癌患者中的作用,按年龄组划分
Heenaben Patel1, Ponnandai Somasundar2, N Joseph Espat3
1Department of Medicine, Roger Williams Medical Center, Providence, RI, USA.
American journal of surgery
|October 25, 2025
概括
甲状腺切除术改善了所有年龄段的转移性分化甲状腺癌 (DTC) 患者的生存率. 然而,老年人可能在获得这一关键手术方面存在差异,这会影响整体生存率.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 流行病学 流行病学
背景情况:
- 转移性分化甲状腺癌 (DTCs) 可以呈现临床休眠状态.
- 早期甲状腺切除术对转移性DTC不同年龄组的生存的影响尚不清楚.
研究的目的:
- 研究甲状腺切除术对转移性DTC患者的整体存活时间 (OS) 的影响.
- 分析按年龄组的生存结果,并评估手术干预的潜在差异.
主要方法:
- 利用国家癌症数据库 (NCDB) 对在2010-2021年期间被诊断患有转移性乳头/细胞癌的患者.
- 采用多变量Cox比例危险模型来分析整体存活率 (OS).
主要成果:
- 总共有5735名转移性DTC患者被分析;72.29%的患者在≥55.5岁时被诊断出来.
- 甲状腺切除术与较年轻 (<55) 和较老 (≥55) 的年龄组 (HR分别为0.25和0.29) 的生存系统改善有关.
- 在两周内接受手术的年轻患者的生存率提高,老年人甲状腺切除率较低.
结论:
- 甲状腺切除术显著改善了转移性DTC患者在所有年龄群体的生存率.
- 对于转移性DTC的老年人来说,手术利用的潜在差异存在,需要进一步调查.
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