在COVID-19之后,急性状肌痛炎的发展特征:四个案例系列
Qingqing Wang1, Vettaikorumakankav Vedanarayanan1, Chang Y Ho2
1Pediatric Neurosciences, Dell Children's Medical Center, UT Health Austin, Austin, Texas; Department of Neurology, Dell Medical School, The University of Texas at Austin, Austin, Texas.
Pediatric neurology
|October 25, 2025
概括
流行后的急性软性脑膜炎 (AFM) 病例显示出不断演变的,不典型的临床特征. 在一些患者中发现了D68肠道病毒,而维生素D缺乏可能会影响这种罕见的类似脊髓灰质炎疾病的预后.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 急性软性脑膜炎 (AFM) 是一种罕见的,类似于脊髓灰质炎的疾病,通常在儿童中引起.
- AFM爆发通常遵循两年一次的模式,但COVID-19大流行可能改变了它的流行病学.
- 本研究研究了四个流行后的AFM病例,以了解不断变化的临床特征和结果.
研究的目的:
- 在COVID-19大流行开始后,探索急性软性脑膜炎 (AFM) 的不断变化的临床特征.
- 为了确定在流行后的AFM病例中结果的潜在预测因素.
主要方法:
- 疾病控制和预防中心确认的四例AFM病例的医疗记录的回顾性审查.
- 对人口统计数据,临床表现,诊断调查,治疗和患者结果的分析.
主要成果:
- 病例呈现异常特征,包括年龄较大,缺乏病毒前,感官症状和对称虚弱.
- 所有患者都出现了肠/膀功能障碍;两人有持续的症状.
- 脊柱MRI显示灰质参与,但与严重程度无关;电诊断研究表明严重的运动神经元损伤.
- 肠道病毒D68在两个病例中被检测到;在所有测试患者中都发现了低维生素D水平.
结论:
- 流行病后的AFM病例表现出更广泛,不断发展的临床谱,可能受到流行病相关因素的影响.
- 核磁共振成像的发现不能预测严重程度,而电诊断研究更有信息性.
- 维生素D缺乏和其他因素可能会影响AFM的预后,因此需要进一步研究.
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