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基于二元脂质系统的颗粒与未溶解的药物晶体通过防止降解和改善透性来增强口服生物可用性

Xiaowei Dong1, Tao Zhang2, Liangqiao Bian3

  • 1Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA.

International journal of pharmaceutics
|October 25, 2025
PubMed
概括

这项研究为olmesartan medoxomil (OLM) 开发了新的脂质固体颗粒 (LSG),在不溶解药物的情况下,提高了625%的口服生物可用性. 这种方法可以保护OLM免受降解,并改善难溶性前药物的吸收.

关键词:
药物降解 药物的降解药物固体颗粒是药物的固体颗粒.脂质和表面活性剂的使用.口服吸收增强剂口服吸收增强剂它们是前药物.在水中不溶的药物.

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